Novel Multiple Mutations in the Topoisomerase Gene of Haitian Variant Vibrio cholerae O1
نویسندگان
چکیده
منابع مشابه
Novel multiple mutations in the topoisomerase gene of Haitian variant Vibrio cholerae O1.
Cholera has reinstated its deadly grip on the planet with recent epidemics in Zimbabwe and Haiti (1, 2), along with the emergence of Vibrio cholerae having reduced susceptibility to fluoroquinolones. India also experiences frequent outbreaks caused by multidrug-resistant V. cholerae (3). We report reduced sensitivity to ciprofloxacin in V. cholerae O1 El Tor Ogawa and novel multiple mutations i...
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Priyanka Ghosh, Arindam Naha, Surajit Basak, Santanu Ghosh, T. Ramamurthy, Hemanta Koley, Ranjan K. Nandy, Sumio Shinoda, Haruo Watanabe, Asish K. Mukhopadhyay Division of Bacteriology, National Institute of Cholera and Enteric Diseases (NICED), Kolkata, India; Department of Molecular Biology & Bioinformatics and Bioinformatics Centre, Tripura University, Tripura, India; Collaborative Research ...
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Until the discovery of the Vibrio cholerae repeat (VCR), the gene capture and expression systems termed integrons had been typically associated with antibiotic-resistance gene cassettes with usually less than five genes in an array. A method is described for the cloning of the ends of large cassette arrays. Conserved restriction sites within VCRs facilitated the mapping by Southern hybridizatio...
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regions would be conserved differently must be considered. It is probable that subsequent sequences of HGyVs remain to be identified in human blood. A recent study reported the characterization of a highly divergent GyV sequence (GyV4) in human fecal samples and chicken meat (7); as with avian GyV2 and GyV3, further research is needed to determine whether this variant replicates in the human bo...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.03189-14